Video: Question: APP processing and synaptic function.

At the conclusion of the panel discussion, the floor was opened to questions from the audience. In this first question, Hélène Marie (IPMC and CNRS, France) asks whether APP processing (and the various resulting fragments) may play a substantive role in normal, physiological regulation of synaptic function and whether perturbations to this system may then underlie toxicity and synaptic dysfunction which occurs during the early stages of the disease.

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Nature Neuroscience presents a panel discussion by several leaders in the field of Alzheimer’s disease (AD) research in which we take a critical look at the many (sometimes seemingly contradictory) facets of AD pathogenesis and progression.

Tim Spencer

Senior Editor, Nature Neuroscience

Tim Spencer received his PhD from the City University of New York, where he studied the signaling mechanisms which underlie the promotion of axonal growth and regeneration following injury in the laboratory of Marie Filbin. He then moved to the laboratory of Chris Henderson at Columbia University, where he examined molecular markers of postnatal motor neuron maturation and elements of neurodegenerative diseases such as ALS and SMA. His research interests include neuronal development and maturation, axonal guidance and models of neuronal disease and dysfunction. Tim joined the editorial team of Nature Neuroscience in March of 2011, where he handles many of the manuscripts on neural development and neurogenesis, neurodegeneration, neuroinflammation and neuroimmune interactions, myelination/remyelination, molecular and cellular pathways, and "brain cancer" (glioblastoma, etc.).