Video: Aβ versus APP processing in AD pathogenesis.

In this second video of the series, the panelists discuss the potential roles of APP processing and intracellular Aβ accumulation in the induction of toxicity and synaptic dysfunction.

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Nature Neuroscience presents a panel discussion by several leaders in the field of Alzheimer’s disease (AD) research in which we take a critical look at the many (sometimes seemingly contradictory) facets of AD pathogenesis and progression.

Tim Spencer

Senior Editor, Nature Neuroscience

Tim Spencer received his PhD from the City University of New York, where he studied the signaling mechanisms which underlie the promotion of axonal growth and regeneration following injury in the laboratory of Marie Filbin. He then moved to the laboratory of Chris Henderson at Columbia University, where he examined molecular markers of postnatal motor neuron maturation and elements of neurodegenerative diseases such as ALS and SMA. His research interests include neuronal development and maturation, axonal guidance and models of neuronal disease and dysfunction. Tim joined the editorial team of Nature Neuroscience in March of 2011, where he handles many of the manuscripts on neural development and neurogenesis, neurodegeneration, neuroinflammation and neuroimmune interactions, myelination/remyelination, molecular and cellular pathways, and "brain cancer" (glioblastoma, etc.).


Go to the profile of Zemin Wang
over 6 years ago
Hi Tim, Could you upload the whole episode of the discussion? Thanks, Zemin
Go to the profile of Tim Spencer
over 6 years ago
Hi Zemin, Thank you for the comment. We will be posting new video segments of the forum each week, split by discussion topic, along with associated papers/content. All of the relevant topics discussed during the forum will be posted eventually (within the next month or so). Thanks again. Tim