Rescue of long-range circuit dysfunction in Alzheimer's disease models.
Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, and Konnerth A
Slow-wave oscillations are known to be important for non-REM sleep as well as information integration and memory consolidation. In this study, the authors show that long-range coherence of slow-wave oscillations are disrupted in AD mouse models (and in response to Aβ exposure) and this effect can be rescued by manipulations which reduce circuit hyperactivity.
Read the full article on Readcube for free here.Nat Neurosci. 2015 Nov;18(11):1623-30. doi: 10.1038/nn.4137