Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.

Palop JJ and Mucke L

Go to the profile of Tim Spencer
Dec 08, 2015
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This review article discusses current hypotheses regarding the effect of oligomeric Aβ on the regulation of synaptic activity and changes in neuronal circuit/network function and how this may underlie cognitive decline in Alzheimer’s disease patients and animals models.

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Nat Neurosci. 2010 Jul;13(7):812-8. doi: 10.1038/nn.2583
Go to the profile of Tim Spencer

Tim Spencer

Senior Editor, Nature Neuroscience

Tim Spencer received his PhD from the City University of New York, where he studied the signaling mechanisms which underlie the promotion of axonal growth and regeneration following injury in the laboratory of Marie Filbin. He then moved to the laboratory of Chris Henderson at Columbia University, where he examined molecular markers of postnatal motor neuron maturation and elements of neurodegenerative diseases such as ALS and SMA. His research interests include neuronal development and maturation, axonal guidance and models of neuronal disease and dysfunction. Tim joined the editorial team of Nature Neuroscience in March of 2011, where he handles many of the manuscripts on neural development and neurogenesis, neurodegeneration, neuroinflammation and neuroimmune interactions, myelination/remyelination, molecular and cellular pathways, and "brain cancer" (glioblastoma, etc.).

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