Intracellular amyloid-beta in Alzheimer's disease.
LaFerla FM, Green KN, and Oddo S
As noted in the panel discussion (see the video here), there is a substantial amount of evidence in the literature suggesting a role for intracellular Aβ accumulation in the induction of Alzheimer’s disease-related toxicity. This review article from Nature Reviews Neuroscience illustrates some the key studies which support this hypothesis.
Read the full article on Readcube for free here.
Nat Rev Neurosci. 2007 Jul;8(7):499-509. doi:10.1038/nrn2168
Also, see these other important papers for more on this
Am J Pathol. 2002 Nov;161(5):1869-79.
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK.
Am J Pathol. 2006 Jan;168(1):184-94.
A dynamic relationship between intracellular and extracellular pools of Abeta.
Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM.