Latest Questions

Animal Models for Sporadic AD

Go to the profile of Apurva Agrawal
Apurva Agrawal on Apr 18, 2016 • 1 answer
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Thank you for this question. I have been looking the most appropriate AD models for a whi... Read more »
Go to the profile of Mehmet Bostancıklıoğlu
Mehmet Bostancıklıoğlu on Apr 18, 2016
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Evidence for or against CDK5 as a valid target in AD?

Go to the profile of Kent Werner
Kent Werner on Mar 16, 2016 • 2 answer
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Dear Karl, Thank you for your thoughtful answer. Indeed the conditional knockout produced in the Bibb lab at UTSW was revealing both of positive and negative effec... Read more »
Go to the profile of Kent Werner
Kent Werner on Mar 18, 2016
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at the moment considering the negative results for long time-see Elan and Dale Schenk invention about monoclonal antibody in Alzheimer-is still useful to rely on neuro inflammatory hypothesis?

Go to the profile of Alain Mititelu
Alain Mititelu on Feb 09, 2016 • 2 answer
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Hi Alain I have to confess that I'm puzzled by the framing of your question. I suspect what you mean is that given the poor results in relationship to monoclonal antibodies is is still useful to rely on the amyloid hypothes... Read more »
Go to the profile of Douglas F Watt
Douglas F Watt on Mar 02, 2016
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I am collaborating with a group of scientists and clinicians interested in metabolic correction of mitochondrial dysfunction in neurodegenerative disease. Any interest in the topic in this forum?

Go to the profile of Barry James Barclay
Barry James Barclay on Dec 30, 2015 • 1 answer
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I am very interested in determining wether correction pf mitochondrial dysfunction prevents cognitive deficits in Alzheimer' Disease and I think this may be a very interesting topic for a discussion forum
Go to the profile of Ramon
Ramon on Feb 23, 2016
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Hi Tim, this place of discussion is great! I am wondering if mathematical models have brought any light to the understanding of DA. Thanks and warm regards from Brazil. Mauricio.

Go to the profile of Mauricio Souza
Mauricio Souza on Dec 15, 2015 • 2 answer
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In terms of mathematical modeling in general and Quantitative Systems Pharmacology (QSP) in particular, we have developed a mechanism-based computer platform, based on the neurophysiology and neuropharmacology of biophysically realistic neuronal circuit networks and implemented with an Alzheimer pathology. This model for symptomatic cognitive effects is calibrated with ADAS-Cog data on 28 different drug-dose-trial duration scenarios (Roberts et ... Read more »
Go to the profile of Hugo Geerts
Hugo Geerts on Jan 25, 2016
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I am working on a project searching for drugs from plants against Alzheimer disease. Do you think we can have a success?

Go to the profile of Paul Moundipa
Paul Moundipa on Nov 17, 2015 • 4 answer
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Yes sure. You have to look for traditional knowledge where people without knowing scientific background uses herbs for memory enhancement.
Go to the profile of Dr Ram Singh
Dr Ram Singh on Jan 05, 2016
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How does this Forum section of Nature Neuroscience - key issues in Alzheimer's Disease work?

Go to the profile of Reya Silao
Reya Silao on Oct 21, 2015 • 1 answer
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Thanks for asking this question Reya! Any signed-up Member, Panelist or Editor can ask a question in the For... Read more »
Go to the profile of Jen Thoroughgood
Jen Thoroughgood on Oct 21, 2015
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