Rescue of long-range circuit dysfunction in Alzheimer's disease models.

Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, and Konnerth A

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Slow-wave oscillations are known to be important for non-REM sleep as well as information integration and memory consolidation. In this study, the authors show that long-range coherence of slow-wave oscillations are disrupted in AD mouse models (and in response to Aβ exposure) and this effect can be rescued by manipulations which reduce circuit hyperactivity.

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Nat Neurosci. 2015 Nov;18(11):1623-30. doi: 10.1038/nn.4137

Tim Spencer

Senior Editor, Nature Neuroscience

Tim Spencer received his PhD from the City University of New York, where he studied the signaling mechanisms which underlie the promotion of axonal growth and regeneration following injury in the laboratory of Marie Filbin. He then moved to the laboratory of Chris Henderson at Columbia University, where he examined molecular markers of postnatal motor neuron maturation and elements of neurodegenerative diseases such as ALS and SMA. His research interests include neuronal development and maturation, axonal guidance and models of neuronal disease and dysfunction. Tim joined the editorial team of Nature Neuroscience in March of 2011, where he handles many of the manuscripts on neural development and neurogenesis, neurodegeneration, neuroinflammation and neuroimmune interactions, myelination/remyelination, molecular and cellular pathways, and "brain cancer" (glioblastoma, etc.).