Rescue of long-range circuit dysfunction in Alzheimer's disease models.
Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, and Konnerth A
Slow-wave oscillations are known to be important for non-REM sleep as well as information integration and memory consolidation. In this study, the authors show that long-range coherence of slow-wave oscillations are disrupted in AD mouse models (and in response to Aβ exposure) and this effect can be rescued by manipulations which reduce circuit hyperactivity.
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Nat Neurosci. 2015 Nov;18(11):1623-30. doi: 10.1038/nn.4137