Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.
Palop JJ and Mucke L
This review article discusses current hypotheses regarding the effect of oligomeric Aβ on the regulation of synaptic activity and changes in neuronal circuit/network function and how this may underlie cognitive decline in Alzheimer’s disease patients and animals models.
Read the full article on Readcube for free here.Nat Neurosci. 2010 Jul;13(7):812-8. doi: 10.1038/nn.2583