Single App knock-in mouse models of Alzheimer's disease.
Takashi Saito, Yukio Matsuba, Naomi Mihira, Jiro Takano, Per Nilsson, Shigeyoshi Itohara, Nobuhisa Iwata and Takaomi C Saido
One of the most pressing issues in modern AD research is the inability to tease out whether pathology observed in many mutant mouse lines is due to the mutation/protein dysfunction or due to the aberrant overexpression of APP and/or PS1. In this study, the authors generated one of the first mouse lines which express mutant APP at physiological levels.
Read the full article on Readcube for free here.
Nat Neurosci. 2014 May;17(5):661-3. doi: 10.1038/nn.3697
Also, click here to see the recent panel discussion by Dr. Saido and other AD experts on ALZforum regarding this new animal model and the problems faced by the field when trying to interpret animal model data.