Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.
Berislav V. Zlokovic
In addition to the many cellular insults which may contribute to neurodegeneration, there is also a wealth of evidence which suggests that dysfunction of the blood-brain barrier and other CNS vascular insults may also play a key role in Alzheimer’s Disease pathogenesis. This review from Berislav Zlokovic describes much of the recent work into understand how BBB dysfunction contributes to neurodegeneration.
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Nat Rev Neurosci. 2011 Nov 3;12(12):723-38. doi: 10.1038/nrn3114