Intracellular amyloid-beta in Alzheimer's disease.

LaFerla FM, Green KN, and Oddo S

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As noted in the panel discussion (see the video here), there is a substantial amount of evidence in the literature suggesting a role for intracellular Aβ accumulation in the induction of Alzheimer’s disease-related toxicity. This review article from Nature Reviews Neuroscience illustrates some the key studies which support this hypothesis.

Read the full article on Readcube for free here.

Nat Rev Neurosci. 2007 Jul;8(7):499-509. doi:10.1038/nrn2168

Also, see these other important papers for more on this topic:
Am J Pathol. 2002 Nov;161(5):1869-79.
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK.

Am J Pathol. 2006 Jan;168(1):184-94.
A dynamic relationship between intracellular and extracellular pools of Abeta.
Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM.

Tim Spencer

Senior Editor, Nature Neuroscience

Tim Spencer received his PhD from the City University of New York, where he studied the signaling mechanisms which underlie the promotion of axonal growth and regeneration following injury in the laboratory of Marie Filbin. He then moved to the laboratory of Chris Henderson at Columbia University, where he examined molecular markers of postnatal motor neuron maturation and elements of neurodegenerative diseases such as ALS and SMA. His research interests include neuronal development and maturation, axonal guidance and models of neuronal disease and dysfunction. Tim joined the editorial team of Nature Neuroscience in March of 2011, where he handles many of the manuscripts on neural development and neurogenesis, neurodegeneration, neuroinflammation and neuroimmune interactions, myelination/remyelination, molecular and cellular pathways, and "brain cancer" (glioblastoma, etc.).