Intracellular Aβ and APP processing

While many studies have focused on the potential toxicity of extracellular Aβ aggregation, there yet other studies which have implicated other APP-derived fragments in Alzheimer’s disease pathogenesis. Furthermore, there is also evidence which suggests that the intracellular accumulation of Aβ may be as (or even more) important than extracellular aggregation for the onset of AD pathology.